Behavioral response and transmitter release during atonia elicited by medial 1 medullary
نویسندگان
چکیده
1 medullary stimulation 2 3 Yuan-Yang Lai, Tohru Kodama, Elizabeth Schenkel and Jerome M. Siegel 4 5 Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, 6 UCLA and VAGLAHS Sepulveda, North Hills, CA 91343 and Department of 7 Psychology, Tokyo Metropolitan Institute for Medical Research, Tokyo, Japan 8 9 Running title: state-dependent response to medulla activation. 10 11 12 13 Correspondence: 14 Yuan-Yang Lai, Ph.D. 15 Neurobiology Research 151A3 16 VAGLAHS Sepulveda 17 16111 Plummer Street 18 North Hills, CA 91343 19 Phone: 818-891-7711x7569 20 Fax: 818-895-9575 21 e-mail: [email protected] 22 23 Articles in PresS. J Neurophysiol (July 28, 2010). doi:10.1152/jn.00528.2010
منابع مشابه
Behavioral response and transmitter release during atonia elicited by medial medullary stimulation.
Activation of the medial medulla is responsible for rapid eye movement (REM) sleep atonia and cataplexy. Dysfunction can cause REM sleep behavior disorder and other motor pathologies. Here we report the behavioral effects of stimulation of the nucleus gigantocellularis (NGC) and nucleus magnocellularis (NMC) in unrestrained cats. In waking, 62% of the medial medullary stimulation sites suppress...
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pontine reticular formation induces rapid-eye-movement (REM) sleep with atonia in intact animals, and lesions at this pontine site cause REM sleep without atonia.1,2,3 REM sleep without atonia is also induced by lesions in the medial medulla.4,5 In the decerebrate cat, both chemical and electrical stimulation delivered to the pontine inhibitory regions, as well as to portions of the medial medu...
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Electrical stimulation studies have implicated the medial medulla in the inhibition of muscle tone. In the present report we present evidence for suppression of muscle tone by chemical activation of the medial medulla. We find 2 distinct zones within the classically defined medial medullary inhibitory area. A rostral region corresponding to the nucleus magnocellularis (NMC) is sensitive to glut...
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The dorsolateral pontine inhibitory area (PIA) and medial medullary reticular formation (MMRF) have been found to mediate the muscle atonia of REM sleep. Our previous studies have shown that acetylcholine (ACh) microinjection in the PIA and in the nucleus paramedianus of the medial medulla produces muscle atonia. Glutamate microinjection in both PIA and nucleus magnocellularis (NMC) of the medi...
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Muscle atonia is a central feature of adult REM sleep which has recently been demonstrated to be a component of sleep in rats as young as 2 days of age (P2). The neural generation of atonia, which depends on mesopontine and medullary structures, is not fully understood in adults and has never been described in infants. In the present experiments we used electrical stimulation in decerebrated pu...
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